Rhinitis, sinusitis and ocular disease – 2095. Inhibitory effect of Ginsenoside Rg1 on extracellular matix production via extracellular signal-regulated protein Kinase/ activator Protein 1 pathway in nasal polyp-derived fibroblasts
نویسندگان
چکیده
Background Nasal polyps are associated with chronic inflammation of the sinonasal mucosa and are involved in myofibroblast differentiation and extracellular matrix (ECM) accumulation. Ginsenoside Rg1, a compound derived from Panax ginseng, shows antifibrotic and anticancer effects. However, the molecular effects of Rg1 on myofibroblast differentiation and ECM production remain unknown. The aims of this study were to investigate the effect of Rg1 on transforming growth factor (TGF)-b1-induced myofibroblast differentiation and ECM production and to determine the molecular mechanism of Rg1 in nasal polyp-derived fibroblasts (NPDFs).
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